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Translational Innovation and Therapies Using S-Nitrosothiols
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Publications

Riley CM, Wenzel SE, Castro M, Erzurum SC, Chung KF, Fitzpatrick AM, Gaston B, Israel E, Moore WC, Bleecker ER, Calhoun WJ, Jarjour NN, Busse WW, Peters SP, Teague WG, Sorkness R, Holguin F. Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma. PLoS One. 2015 Dec 30;10(12):e0145476. doi:10.1371/journal.pone.0145476. eCollection 2015. PubMed PMID: 26717486. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145476

Zaman K, Sawczak V, Zaidi A, Butler M, Bennett D, Getsy P, Zeinomar M, Greenberg Z, Forbes MS, Rehman S, Jyothikumar V, DeRonde K, Sattar A, Smith L, Corey DA, Straub A, Sun F, Palmer L, Periasamy A, Randell SH, Kelley TJ, Lewis SJ, Gaston B. Augmentation of CFTR maturation by S-nitrosoglutathione reductase. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 4:ajplung.00269.2014. doi:10.1152/ajplung.00269.2014. [Epub ahead of print] PubMed PMID: 26637637. http://ajplung.physiology.org/content/ajplung/early/2015/12/02/ajplung.00269.2014.full.pdf

Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B. Erratum. Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Eur Respir J. 2015 Jun;45(6):1763. doi:10.1183/09031936.50042414. PubMed PMID: 26028625. http://erj.ersjournals.com/lookup/pmidlookup?view=long&pmid=26028625

Shein SL, Li H, Gaston B. Blood eosinophilia is associated with unfavorable hospitalization outcomes in children with bronchiolitis. Pediatr Pulmonol. 2015 Jun 9. doi: 10.1002/ppul.23219. [Epub ahead of print] PubMed PMID: 26062028.

Stsiapura VI, Shuali VK, Gaston BM, Lehmann KK. Detection of S-nitroso compounds by use of midinfrared cavity ring-down spectroscopy. Anal Chem. 2015 Mar 17;87(6):3345-53. doi: 10.1021/ac5045143. Epub 2015 Mar 3. PubMed PMID:25692741.

Marozkina NV, Gaston B. Nitrogen chemistry and lung physiology. Annu Rev Physiol. 2015;77:431-52. doi: 10.1146/annurev-physiol-021113-170352. PubMed PMID:25668023.

Sawczak V, Getsy P, Zaidi A, Sun F, Zaman K, Gaston B. Novel Approaches for Potential Therapy of Cystic Fibrosis. Curr Drug Targets. 2015 Jan 1. [Epub ahead of print] PubMed PMID: 25557257.

Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B. Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Eur Respir J. 2015 Jan;45(1):87-97. doi:10.1183/09031936.00042414. Epub 2014 Oct 30. PubMed PMID: 25359343; PubMed Central PMCID: PMC4283933.

Modena BD, Tedrow JR, Milosevic J, Bleecker ER, Meyers DA, Wu W, Bar-Joseph Z, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Wenzel SE. Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways. Am J Respir Crit Care Med. 2014 Dec 15;190(12):1363-72. doi: 10.1164/rccm.201406-1099OC. PubMed PMID: 25338189; PubMed Central PMCID: PMC4294630.

Palmer LA, Kimberly deRonde, Brown-Steinke K, Gunter S, Jyothikumar V, Forbes MS, Lewis SJ. Hypoxia-induced changes in protein s-nitrosylation in female mouse brainstem. Am J Respir Cell Mol Biol. 2015 Jan;52(1):37-45. doi:10.1165/rcmb.2013-0359OC. PubMed PMID: 24922346; PubMed Central PMCID:PMC4370248.

Burdikova Z, Svindrych Z, Pala J, Hickey CD, Wilkinson MG, Panek J, Auty MA, Periasamy A, Sheehan JJ. Measurement of pH micro-heterogeneity in natural cheese matrices by fluorescence lifetime imaging. Front Microbiol. 2015 Mar 6;6:183. doi:10.3389/fmicb.2015.00183. eCollection 2015. PubMed PMID: 25798136; PubMed Central PMCID: PMC4351631.

Sun Y, Periasamy A. Localizing protein-protein interactions in living cells using fluorescence lifetime imaging microscopy. Methods Mol Biol. 2015;1251:83-107. doi: 10.1007/978-1-4939-2080-8_6. PubMed PMID: 25391796.

Palmer LA, May WJ, deRonde, K, Brown-Steinke K, Lewis SJ. Hypoxia-induced ventilatory responses in conscious mice: Gender differences in ventilatory roll-off and facilitation. Resp Physiol Neurobiol. 185: 497-505, 2013.

Palmer LA, May WJ, deRonde K, Brown-Steinke K, Gaston B, Bates JN, Lewis SJ. Ventilatory responses during and following exposure to a hypoxic challenge in conscious mice deficient or null in S-nitrosoglutathione reductase. Resp Physiol Neurobiol. 185: 571-581, 2013.

Young AP, Gruber RB, Discala JF, May WJ, Palmer LA, Lewis SJ. Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite. Resp Physiol Neurobiol. 186: 255-264, 2013.

Henderson F, May WJ, Gruber R, Young AP, Palmer LA, Gaston B, Lewis SJ. Low dose morphine elicits ventilatory excitant and depressant responses in conscious rats: Role of peripheral µ-opioid receptors. Open J Mol Integ Physiol. 3: 111-124, 2013.

May WJ, Henderson F, Gruber RB, Discala JF, Young AP, Bates JN, Palmer LA, Lewis SJ. Morphine has latent deleterious effects on the ventilatory responses to a hypoxic-hypercapnic challenge. Open J Mol Integ Physiol. 3: 134-145, 2013.

Mendoza J, Passafaro R, Baby S, Young AP, Bates JN, Gaston B, Lewis SJ. L-Cysteine ethyl ester reverses the deleterious effects of morphine on arterial blood-gas chemistry in tracheotomized rats. Resp Physiol Neurobiol. 189: 136-143, 2013.

Chelko SP, Schmiedt CW, Lewis TH, Lewis SJ, Robertson TP. Vasopressin-induced constriction of the isolated rat occipital artery is segment-dependent. J Vasc Res. In press, 2013.

Chelko SP, Schmiedt CW, Lewis TH, Lewis SJ, Robertson TP. A novel vascular clip design for the reliable induction of 2-kidney, 1-clip hypertension in the rat. J Appl Physiol. 112: 362-366, 2012.

Hernandez SM, Schumacher J, Lewis SJ, Odoi A, Divers SJ. Selected cardiopulmonary values and baroreceptor reflex in conscious green iguanas (Iguana iguana). Am J Vet Res. 72: 1519-1526, 2011.

Kanbar R, Stornetta RL, Cash DR, Lewis SJ, Guyenet PG. Photostimulation of Phox2b medullary neurons activates cardiorespiratory function in conscious rats. Am J Respir Crit Care Med. 182: 1184-1194, 2010.

Lewis SJ, Gaston B. S-Nitrosothiol deficiency in asthma. Am J Respir Crit Care Med. 180: 198-199, 2009.

Sousa R, Halper J, Zhang J, Lewis SJ, Li WI. Effect of Lactobacillus acidophilus supernatants on body weight and leptin expression in rats. BMC Complement Altern Med. 8: 5, 2008.

Kim BH, Sandock KD, Robertson TP, Lewis SJ, Akoh CC. Dietary structured lipids and phytosteryl esters: blood lipids and cardiovascular status in spontaneously hypertensive rats. Lipids 43: 55-64, 2008.

Whalen EJ, Lewis SJ, Johnson AK. Hemodynamic responses elicited by γ2-MSH or blood replacement in hemorrhaged rats. J Surg Res. 139: 121-127, 2007.

Robertson TP, Peroni JF, Noschka E, Lewis TH, Grafton ME, Lewis SJ, Moore JN. Effects of Rho-kinase or Src protein tyrosine kinase inhibition on agonist-induced constriction of arteries and veins of the equine laminar dermis. Am J Vet Res. 68: 886-894, 2007.

Kim BH, Sandock KD, Robertson TP, Lewis SJ, Akoh CC. Dietary effects of structured lipids and phytosteryl esters on cardiovascular function in Spontaneously Hypertensive rats. J Cardiovasc Pharmacol. 50: 178-186, 2007.

Hashmi-Hill MP, Graves JE, Sandock K, Bates JN, Robertson TP, Lewis SJ. Hemodynamic responses elicited by systemic injections of flavin adenine dinucleotide in anesthetized rats. J Cardiovasc Pharmacol. 50: 94-102, 2007.

Hashmi-Hill MP, Sandock K, Bates JN, Robertson TP, Lewis SJ. Flavin adenine dinucleotide may release preformed stores of nitrosyl factors from the vascular endothelium of conscious rats. J Cardiovasc Pharmacol. 50: 142-154, 2007.

Lewis SJ, Owen JR, Bates JN. S-nitrosocysteine elicits hemodynamic responses similar to those of the Bezold-Jarisch reflex via activation of stereoselective recognition sites. Eur J Pharmacol. 531: 254-258, 2006.

Possas O, Johnson AK, Lewis SJ. Role of nitrosyl factors in the hindlimb vasodilation produced by baroreceptor afferent nerve stimulation. Am J Physiol. 290: R741-R748, 2006.

Graves JE, Kooy NW, Lewis SJ. L-β,β-dimethylcysteine attenuates the hemodynamic responses elicited by systemic injections of peroxynitrite in anesthetized rats. Brit J Pharmacol. 148: 7-15, 2006.

Whalen EJ, Bates JN, Johnson AK, Lewis SJ. Down-regulation of propranolol-sensitive β-adrenoceptor signaling after inhibition of nitric oxide synthesis. Brit J Pharmacol. 147: 755-764, 2006.

Owen JR, Bates JN, Lewis SJ. Differential effects of nitroblue tetrazolium on the hemodynamic responses elicited by activation of α1-adrenoceptors and 5-HT2 receptors in conscious rats. Eur J Pharmacol. 535: 248-252, 2006.

Lewis SJ, Hashmi-Hill MP, Owen JR, Sandock K, Robertson TP, Bates JN. The vasodilator potency of the endothelium-derived relaxing factor, L-S-nitrosocysteine, is impaired in Spontaneously Hypertensive rats. Vasc Pharmacol. 44: 476-490, 2006.

Lewis SJ, Hashmi-Hill MP, Owen JR, Sandock K, Robertson TP, Bates JN. ACE inhibition restores the vasodilator potency of the endothelium-derived relaxing factor, L-S-nitrosocysteine, in Spontaneously Hypertensive rats. Vasc Pharmacol. 44: 491-507, 2006.

Whalen EJ, Saurer TB, Johnson AK, Lewis SJ. Intracellular cGMP may promote Ca2+-dependent and Ca2+-independent release of catecholamines from sympathetic nerve terminals. Vasc Pharmacol. 45: 102-111, 2006.

Lacolley P, Owen JR, Bates JN, Johnson AK, Lewis SJ. Tachyphylaxis to 5-HT3 receptor-mediated activation of vagal afferents is prevented by co-activation of 5-HT2 receptors. Brain Res. 1093: 105-115, 2006.

Lewis SJ, Travis MD, Hashmi-Hill MP, Sandock K, Robertson TP, Bates JN. Differential effects of ouabain on the vasodilator actions of nitric oxide and S-nitrosothiols in vivo. Vasc Pharmacol. 45: 383-394, 2006.

Lewis SJ, Hoque A, Sandock K, Robertson TP, Bates JN, Kooy NW. Differential effects of peroxynitrite on the function of arginine vasopressin V1a receptors and alpha1-adrenoceptors in vivo. Vasc Pharmacol, 46: 24-34, 2006.

Lacolley P, Owen JR, Sandock K, Lewis TH, Bates JN, Robertson TP, Lewis SJ. Occipital artery injections of 5-HT may directly activate the cell bodies of vagal and glossopharyngeal afferent cell bodies in the rat. Neuroscience 143: 289-308, 2006.

Lacolley P, Owen JR, Sandock K, Lewis TH, Bates, Robertson TP, Lewis SJ. 5-HT activates vagal afferent cell bodies in vivo: Role of 5-HT2 and 5-HT3 receptors. Neuroscience 143: 273-287, 2006.

Lewis SJ, Hoque A, Bates JN. Differentiation of L- and D-S-nitrosothiol recognition sites. J Cardiovasc Pharmacol. 46: 660-671, 2005.

Lewis SJ, Graves JE, Bates JN, Kooy NW. Peroxynitrite elicits dysfunction of stereoselective S-nitrosocysteine recognition sites. J Cardiovasc Pharmacol. 46: 637-645, 2005.

Lewis SJ, Hoque A, Walton TM, Kooy NW. Potential role of nitration and oxidation reactions in the effects of peroxynitrite on the function of β-adrenoceptor sub-types in the rat. Eur J Pharmacol. 518: 187-194, 2005.

Hoque A, Owen JR, Bates JN, Lewis SJ. Effects of thiol chelation on α1-adrenoceptor-induced vasoconstriction in vivo. J Cardiovasc Pharmacol. 46: 627-636, 2005.

Graves JE, Lewis SJ, Kooy NW. Loss of K+ATP-channel-mediated vasodilation after induction of tachyphylaxis to peroxynitrite. J Cardiovasc Pharmacol. 46: 646-652, 2005.

Owen JR, Bates JN, Lewis SJ. Endogenous nitrosyl factors may inhibit desensitization of 5-HT3 receptors on vagal cardiopulmonary afferents. Brain Res. 1059: 167-172, 2005.

Graves JE, Lewis SJ, Kooy NW. Role of ATP-sensitive K+-channels in the hemodynamic effects of peroxynitrite in anesthetized rats. J Cardiovasc Pharmacol. 46: 653-659, 2005.

Lewis SJ, Bhopatkar MY, Walton TM, Bates JN. Role of voltage-sensitive calcium-channels in nitric oxide-mediated vasodilation in spontaneously hypertensive rats. Eur J Pharmacol. 528: 144-149, 2005.

Graves JE, Bates JN, Kooy NW, Lewis SJ. Vasodilator actions of the endothelium-derived relaxing factor L-S-nitrosocysteine in anesthetized rats are markedly diminished by peroxynitrite. Clin Exp Physiol Pharmacol. 32: 1137-1141, 2005.

Robertson TP, Peroni JP, Lewis SJ, Moore JN. Effects of induction of capacitative calcium entry on equine laminar microvessels. Am J Vet Res. 66: 1877-1880, 2005.

Sundararajan S, Dodhy SC, Pittman RN, Lewis SJ. Effects of non-leukocyte-reduced and leukocyte-reduced packed red blood cell transfusions on oxygenation of rat spinotrapezius muscle. Microvasc Res. 2014 Jan;91:30-6.

Sun Y, Rombola C, Jyothikumar V, Periasamy A. Förster resonance energy transfer microscopy and spectroscopy for localizing protein-protein interactions  in living cells. Cytometry A. 2013 Sep;83(9):780-93.

Whalen EJ, Johnson AK, Lewis SJ. Hemodynamic responses elicited by systemic injections of isotonic and hypertonic saline in hemorrhaged rats. Microvasc Res. 2014 Jan;91:22-9.

Jyothikumar V, Sun Y, Periasamy A. Investigation of tryptophan-NADH interactions in live human cells using three-photon fluorescence lifetime imaging and Förster resonance energy transfer microscopy.  J Biomed Opt. 2013;18(6):060501.

Wallrabe H, Cai Y, Sun Y, Periasamy A, Luzes R, Fang X, Kan HM, Cameron LC, Schafer DA, Bloom GS. IQGAP1  interactome analysis by in vitro reconstitution and live cell 3-color FRET microscopy.  Cytoskeleton (Hoboken). 2013 Dec;70(12):819-36.

Cechova S, Zeng Q, Billaud M, Mutchler S, Rudy CK, Straub AC, Chi L, Chan FR,  Hu J, Griffiths R, Howell NL, Madsen K, Jensen BL, Palmer LA, Carey RM, Sung SS, Malakauskas SM, Isakson BE, Le TH. Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction. Circulation. 2013 Oct 15;128(16):1770-80.

Zaman K, Fraser-Butler M, Bennett D. Novel s-nitrosothiols have potential therapeutic uses for cystic fibrosis. Curr Pharm Des. 2013;19(19):3509-20. Review. PubMed PMID: 23331028.

Henderson F, May WJ, Gruber RB, Discala JF, Puskovic V, Young AP, Baby SM, Lewis SJ. Role of central and peripheral opiate receptors in the effects of fentanyl on analgesia, ventilation and arterial blood-gas chemistry in conscious rats. Respir Physiol Neurobiol. 2014 Jan 15;191:95-105.

Zaman K, Bennett D, Fraser-Butler M, Greenberg Z, Getsy P, Sattar A, Smith L, Corey D, Sun F, Hunt J, Lewis SJ, Gaston B. S-nitrosothiols increases cystic fibrosis transmembrane regulator expression and maturation in the cell surface. Biochem Biophys Res Commun. 2014 Jan 3. pii: S0006-291X(13)02201-8.

Periasamy A. Advanced light microscopy. Methods. 2014 Mar 15;66(2):121-3. doi: 10.1016/j.ymeth.2014.03.011. PubMed PMID: 24674079. 7:

Gaston B, May WJ, Sullivan S, Yemen S, Marozkina NV, Palmer LA, Bates JN, Lewis SJ. Essential role of hemoglobin beta-93-cysteine in posthypoxia facilitation of breathing in conscious mice. J Appl Physiol (1985). 2014 May 15;116(10):1290-9. doi: 10.1152/japplphysiol.01050.2013. Epub 2014 Mar 7. PubMed PMID: 24610531; PubMed Central PMCID: PMC4044395.

Mendoza JP, Passafaro RJ, Baby SM, Young AP, Bates JN, Gaston B, Lewis SJ. Role of nitric oxide-containing factors in the ventilatory and cardiovascular responses elicited by hypoxic challenge in isoflurane-anesthetized rats. J Appl Physiol (1985). 2014 Jun 1;116(11):1371-81. doi: 10.1152/japplphysiol.00842.2013. Epub 2014 Apr 17. PubMed PMID: 24744389; PubMed Central PMCID: PMC4044398.

Palmer LA, deRonde K, Brown-Steinke K, Gunter S, Jyothikumar V, Forbes MS, Lewis SJ. Hypoxia-Induced Changes in Protein S-nitrosylation in Female Mouse Brainstem. Am J Respir Cell Mol Biol. 2014 Jun 12. [Epub ahead of print] PubMed PMID: 24922346.

Davisson RL, Bates JN, Johnson AK, Lewis SJ. Effects of intracerebroventricular injections of 5-HT on systemic vascular resistances of conscious rats. Microvasc Res. 2014 Sep;95:116-23. doi: 10.1016/j.mvr.2014.08.002. Epub 2014 Aug 14. PubMed PMID: 25128748; PubMed Central PMCID: PMC4188728.

Oliver JL, Kavoussi PK, Smith RP, Woodson RI, Corbett ST, Costabile RA, Palmer LA, Lysiak JJ. The role of regulatory proteins and S-nitrosylation of endothelial nitric oxide synthase in the human clitoris: implications for female sexual function. J Sex Med. 2014 Aug;11(8):1927-35. doi: 0.1111/jsm.12576. Epub 2014 May 16. PubMed PMID: 24836757.

Getsy PM, Davis J, Coffee GA, May WJ, Palmer LA, Strohl KP, Lewis SJ. Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic-hypercapnic gas challenges in conscious mice. Respir Physiol Neurobiol. 2014 Sep 19. pii: S1569-9048(14)00233-X. doi: 10.1016/j.resp.2014.09.006. [Epub ahead of print] PubMed PMID: 25242462.

Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE. Hemoglobin α/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction. Arterioscler Thromb Vasc Biol. 2014 Oct 2. pii: ATVBAHA.114.303974. [Epub ahead of print] PubMed PMID: 25278292.

 

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